G71S (p.Gly71Ser) variant of PRNP (Major prion protein)
G71S (p.Gly71Ser) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
G71S (p.Gly71Ser) variant details
- p.Gly71Ser
- ExAC rs755959420
- gnomAD rs755959420
- Missense
- Variant Prioritization Score for Impact Estimate 0.597
- REVEL 0.53
- CADD 22.20
- PolyPhen-2 1.00
- SIFT 0.44
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available