G71D (p.Gly71Asp) variant of PRNP (Major prion protein)
G71D (p.Gly71Asp) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
G71D (p.Gly71Asp) variant details
- p.Gly71Asp
- gnomAD rs1355212975
- Missense
- Variant Prioritization Score for Impact Estimate 0.649
- REVEL 0.60
- CADD 22.10
- PolyPhen-2 1.00
- SIFT 0.24
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available