G63V (p.Gly63Val) variant of PRNP (Major prion protein)
G63V (p.Gly63Val) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data, published literature, and structural context.
G63V (p.Gly63Val) variant details
- p.Gly63Val
- gnomAD 20-4699408-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.625
- REVEL 0.64
- CADD 23.90
- PolyPhen-2 1.00
- SIFT 0.13
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- Literature evidence available