G63S (p.Gly63Ser) variant of PRNP (Major prion protein)
G63S (p.Gly63Ser) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
G63S (p.Gly63Ser) variant details
- p.Gly63Ser
- TOPMed rs1159538855
- Missense
- Variant Prioritization Score for Impact Estimate 0.626
- REVEL 0.60
- CADD 22.80
- PolyPhen-2 1.00
- SIFT 0.57
- Most common in the East Asian population (allele frequency 5e-05)
- Structural context available