G62S (p.Gly62Ser) variant of PRNP (Major prion protein)
G62S (p.Gly62Ser) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
G62S (p.Gly62Ser) variant details
- p.Gly62Ser
- TOPMed rs1922397920
- Missense
- Variant Prioritization Score for Impact Estimate 0.514
- REVEL 0.52
- CADD 20.60
- PolyPhen-2 0.12
- SIFT 0.18
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available