G58W (p.Gly58Trp) variant of PRNP (Major prion protein)
G58W (p.Gly58Trp) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
G58W (p.Gly58Trp) variant details
- p.Gly58Trp
- ExAC rs773938628
- TOPMed rs773938628
- gnomAD rs773938628
- Missense
- Variant Prioritization Score for Impact Estimate 0.637
- REVEL 0.68
- CADD 27.40
- PolyPhen-2 1.00
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 0.00015)
- Structural context available