G35S (p.Gly35Ser) variant of PRNP (Major prion protein)
G35S (p.Gly35Ser) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
G35S (p.Gly35Ser) variant details
- p.Gly35Ser
- cosmic curated COSV10592
- ExAC rs749207734
- gnomAD rs749207734
- Missense
- Variant Prioritization Score for Impact Estimate 0.61
- REVEL 0.50
- CADD 23.30
- PolyPhen-2 1.00
- SIFT 0.50
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available