G34A (p.Gly34Ala) variant of PRNP (Major prion protein)
G34A (p.Gly34Ala) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
G34A (p.Gly34Ala) variant details
- p.Gly34Ala
- ExAC rs780030584
- gnomAD rs780030584
- Missense
- Variant Prioritization Score for Impact Estimate 0.602
- REVEL 0.55
- CADD 24.80
- PolyPhen-2 0.72
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available