F12S (p.Phe12Ser) variant of PRNP (Major prion protein)
F12S (p.Phe12Ser) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
F12S (p.Phe12Ser) variant details
- p.Phe12Ser
- ExAC rs771239157
- TOPMed rs771239157
- gnomAD rs771239157
- Missense
- Variant Prioritization Score for Impact Estimate 0.6
- REVEL 0.67
- CADD 28.50
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available