R154Q (p.Arg154Gln) variant of PRMT5 (O14744)
R154Q (p.Arg154Gln) in PRMT5 (O14744) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
R154Q (p.Arg154Gln) variant details
- p.Arg154Gln
- TOPMed rs753096989
- Missense
- Variant Prioritization Score for Impact Estimate 0.348
- REVEL 0.06
- CADD 23.50
- PolyPhen-2 0.00
- SIFT 0.42
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available