P88S (p.Pro88Ser) variant of PRMT5 (O14744)
P88S (p.Pro88Ser) in PRMT5 (O14744) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
P88S (p.Pro88Ser) variant details
- p.Pro88Ser
- cosmic curated COSV10508
- ExAC rs757859083
- TOPMed rs757859083
- gnomAD rs757859083
- Missense
- Variant Prioritization Score for Impact Estimate 0.372
- REVEL 0.12
- CADD 21.10
- PolyPhen-2 0.00
- SIFT 0.72
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available