N140S (p.Asn140Ser) variant of PRMT5 (O14744)
N140S (p.Asn140Ser) in PRMT5 (O14744) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
N140S (p.Asn140Ser) variant details
- p.Asn140Ser
- TOPMed rs1284224827
- gnomAD rs1284224827
- Missense
- Variant Prioritization Score for Impact Estimate 0.273
- REVEL 0.05
- CADD 21.30
- PolyPhen-2 0.01
- SIFT 0.13
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available