M4I (p.Met4Ile) variant of PRMT5 (O14744)
M4I (p.Met4Ile) in PRMT5 (O14744) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
M4I (p.Met4Ile) variant details
- p.Met4Ile
- TOPMed rs1338985213
- gnomAD rs1338985213
- Missense
- Variant Prioritization Score for Impact Estimate 0.374
- REVEL 0.10
- CADD 24.80
- PolyPhen-2 0.00
- SIFT 0.16
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available