L86F (p.Leu86Phe) variant of PRMT5 (O14744)
L86F (p.Leu86Phe) in PRMT5 (O14744) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
L86F (p.Leu86Phe) variant details
- p.Leu86Phe
- gnomAD rs1365574312
- Missense
- Variant Prioritization Score for Impact Estimate 0.396
- REVEL 0.23
- CADD 22.60
- PolyPhen-2 0.08
- SIFT 0.17
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available