G7W (p.Gly7Trp) variant of PRMT5 (O14744)
G7W (p.Gly7Trp) in PRMT5 (O14744) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
G7W (p.Gly7Trp) variant details
- p.Gly7Trp
- cosmic curated COSV10457
- gnomAD rs1402305196
- Missense
- Variant Prioritization Score for Impact Estimate 0.542
- REVEL 0.34
- CADD 29.90
- PolyPhen-2 0.95
- SIFT 0.00
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available