G11W (p.Gly11Trp) variant of PRMT5 (O14744)
G11W (p.Gly11Trp) in PRMT5 (O14744) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
G11W (p.Gly11Trp) variant details
- p.Gly11Trp
- NCI-TCGA Cosmic COSV5354
- cosmic curated COSV53545
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.48
- REVEL 0.22
- CADD 32.00
- PolyPhen-2 0.91
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)
- Structural context available