V22L (p.Val22Leu) variant of PRKAR1A (P10644)
V22L (p.Val22Leu) in PRKAR1A (P10644) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.72 / 1. The record also includes population frequency data, published literature, and structural context.
V22L (p.Val22Leu) variant details
- p.Val22Leu
- gnomAD 17-68515463-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.725
- CADD 22.50
- PolyPhen-2 0.01
- SIFT 0.52
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available