R10W (p.Arg10Trp) variant of PRKAA2 (P54646)
R10W (p.Arg10Trp) in PRKAA2 (P54646) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
R10W (p.Arg10Trp) variant details
- p.Arg10Trp
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.308
- REVEL 0.26
- MetaLR 0.22
- MetaSVM -0.80
- CADD 26.20
- PolyPhen-2 0.52
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available