E3K (p.Glu3Lys) variant of PRKAA2 (P54646)
E3K (p.Glu3Lys) in PRKAA2 (P54646) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
E3K (p.Glu3Lys) variant details
- p.Glu3Lys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.404
- REVEL 0.26
- MetaLR 0.22
- MetaSVM -0.79
- CADD 25.10
- PolyPhen-2 0.02
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available