W64R (p.Trp64Arg) variant of POLH (DNA polymerase eta)
W64R (p.Trp64Arg) in POLH (DNA polymerase eta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
W64R (p.Trp64Arg) variant details
- p.Trp64Arg
- TOPMed rs1360464485
- gnomAD rs1360464485
- Missense
- Variant Prioritization Score for Impact Estimate 0.404
- REVEL 0.38
- ESM-1b 0.00
- AlphaMissense 0.64
- MetaLR 0.08
- MetaSVM -0.87
- CADD 23.10
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available