W25S (p.Trp25Ser) variant of POLG (DNA polymerase subunit gamma-1)
W25S (p.Trp25Ser) in POLG (DNA polymerase subunit gamma-1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
W25S (p.Trp25Ser) variant details
- p.Trp25Ser
- TOPMed rs1157410900
- gnomAD rs1157410900
- Missense
- Variant Prioritization Score for Impact Estimate 0.44
- REVEL 0.37
- CADD 22.60
- PolyPhen-2 0.11
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available