R57S (p.Arg57Ser) variant of PLK1 (P53350)
R57S (p.Arg57Ser) in PLK1 (P53350) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
R57S (p.Arg57Ser) variant details
- p.Arg57Ser
- rs757915883
- NCI-TCGA Cosmic COSV5562
- ExAC rs757915883
- gnomAD rs757915883
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.302
- REVEL 0.24
- CADD 24.90
- PolyPhen-2 0.82
- SIFT 0.13
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available