R57C (p.Arg57Cys) variant of PLK1 (P53350)
R57C (p.Arg57Cys) in PLK1 (P53350) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
R57C (p.Arg57Cys) variant details
- p.Arg57Cys
- ExAC rs757915883
- gnomAD rs757915883
- Missense
- Variant Prioritization Score for Impact Estimate 0.361
- REVEL 0.30
- CADD 32.00
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)
- Structural context available