R52H (p.Arg52His) variant of PLK1 (P53350)
R52H (p.Arg52His) in PLK1 (P53350) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
R52H (p.Arg52His) variant details
- p.Arg52His
- ExAC rs750121456
- TOPMed rs750121456
- gnomAD rs750121456
- Missense
- Variant Prioritization Score for Impact Estimate 0.315
- REVEL 0.26
- CADD 23.40
- PolyPhen-2 0.01
- SIFT 0.09
- Most common in the Latino/Admixed American population (allele frequency 6.7e-05)
- Structural context available