R50W (p.Arg50Trp) variant of PLK1 (P53350)
R50W (p.Arg50Trp) in PLK1 (P53350) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data, published literature, and structural context.
R50W (p.Arg50Trp) variant details
- p.Arg50Trp
- gnomAD 16-23679080-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.566
- REVEL 0.50
- CADD 32.00
- PolyPhen-2 0.68
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available
- Literature evidence available