R12W (p.Arg12Trp) variant of PLK1 (P53350)
R12W (p.Arg12Trp) in PLK1 (P53350) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
R12W (p.Arg12Trp) variant details
- p.Arg12Trp
- 1000Genomes rs571545759
- ExAC rs571545759
- TOPMed rs571545759
- gnomAD rs571545759
- Missense
- Variant Prioritization Score for Impact Estimate 0.428
- REVEL 0.32
- CADD 23.90
- PolyPhen-2 0.14
- SIFT 0.01
- Most common in the 1KG:GIH population (allele frequency 0.005)
- Structural context available