R12Q (p.Arg12Gln) variant of PLK1 (P53350)
R12Q (p.Arg12Gln) in PLK1 (P53350) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, published literature, and structural context.
R12Q (p.Arg12Gln) variant details
- p.Arg12Gln
- gnomAD 16-23678967-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.35
- REVEL 0.19
- CADD 23.40
- PolyPhen-2 0.00
- SIFT 0.20
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available
- Literature evidence available