P36L (p.Pro36Leu) variant of PLK1 (P53350)
P36L (p.Pro36Leu) in PLK1 (P53350) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
P36L (p.Pro36Leu) variant details
- p.Pro36Leu
- rs983282909
- ClinGen CA279535620
- ClinVar RCV004326505
- TOPMed rs983282909
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.204
- REVEL 0.17
- CADD 16.80
- PolyPhen-2 0.00
- SIFT 0.11
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available