P28S (p.Pro28Ser) variant of PLK1 (P53350)
P28S (p.Pro28Ser) in PLK1 (P53350) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
P28S (p.Pro28Ser) variant details
- p.Pro28Ser
- rs754746085
- ExAC rs754746085
- TOPMed rs754746085
- gnomAD rs754746085
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.291
- REVEL 0.19
- CADD 11.40
- PolyPhen-2 0.02
- SIFT 0.18
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 7e-05)
- Structural context available