G8R (p.Gly8Arg) variant of PLK1 (P53350)
G8R (p.Gly8Arg) in PLK1 (P53350) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, published literature, and structural context.
G8R (p.Gly8Arg) variant details
- p.Gly8Arg
- gnomAD 16-23678954-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.411
- REVEL 0.18
- CADD 24.00
- PolyPhen-2 0.05
- SIFT 0.27
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- Literature evidence available