G24R (p.Gly24Arg) variant of PLK1 (P53350)
G24R (p.Gly24Arg) in PLK1 (P53350) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
G24R (p.Gly24Arg) variant details
- p.Gly24Arg
- NCI-TCGA Cosmic COSV1002
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.342
- REVEL 0.26
- CADD 16.50
- PolyPhen-2 0.09
- SIFT 0.46
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available