G21V (p.Gly21Val) variant of PLK1 (P53350)
G21V (p.Gly21Val) in PLK1 (P53350) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
G21V (p.Gly21Val) variant details
- p.Gly21Val
- rs765005937
- ClinGen CA7964131
- ClinVar RCV004173620
- ExAC rs765005937
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.363
- REVEL 0.23
- CADD 23.50
- PolyPhen-2 0.01
- SIFT 0.04
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available