G21R (p.Gly21Arg) variant of PLK1 (P53350)
G21R (p.Gly21Arg) in PLK1 (P53350) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
G21R (p.Gly21Arg) variant details
- p.Gly21Arg
- TOPMed rs1959277645
- Missense
- Variant Prioritization Score for Impact Estimate 0.349
- REVEL 0.23
- CADD 23.60
- PolyPhen-2 0.62
- SIFT 0.17
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available