E42K (p.Glu42Lys) variant of PLK1 (P53350)
E42K (p.Glu42Lys) in PLK1 (P53350) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
E42K (p.Glu42Lys) variant details
- p.Glu42Lys
- TOPMed rs1959280716
- Missense
- Variant Prioritization Score for Impact Estimate 0.455
- REVEL 0.25
- CADD 23.80
- PolyPhen-2 0.01
- SIFT 0.16
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available