A27P (p.Ala27Pro) variant of PLK1 (P53350)
A27P (p.Ala27Pro) in PLK1 (P53350) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
A27P (p.Ala27Pro) variant details
- p.Ala27Pro
- ExAC rs780089094
- TOPMed rs780089094
- gnomAD rs780089094
- Missense
- Variant Prioritization Score for Impact Estimate 0.409
- REVEL 0.26
- CADD 21.80
- PolyPhen-2 0.20
- SIFT 0.12
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available