K81N (p.Lys81Asn) variant of PLAU (P00749)
K81N (p.Lys81Asn) in PLAU (P00749) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
K81N (p.Lys81Asn) variant details
- p.Lys81Asn
- rs1208425827
- NCI-TCGA Cosmic COSV1010
- cosmic curated COSV10103
- TOPMed rs1208425827
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.351
- REVEL 0.05
- MetaLR 0.19
- MetaSVM -0.92
- CADD 23.80
- SIFT 0.12
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available