H61L (p.His61Leu) variant of PLAU (P00749)
H61L (p.His61Leu) in PLAU (P00749) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, published literature, and structural context.
H61L (p.His61Leu) variant details
- p.His61Leu
- gnomAD 10-73912311-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.355
- REVEL 0.30
- MetaLR 0.15
- MetaSVM -0.91
- CADD 26.00
- PolyPhen-2 0.46
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available
- Literature evidence available