H25Y (p.His25Tyr) variant of PLAU (P00749)
H25Y (p.His25Tyr) in PLAU (P00749) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
H25Y (p.His25Tyr) variant details
- p.His25Tyr
- ExAC rs753994566
- gnomAD rs753994566
- Missense
- Variant Prioritization Score for Impact Estimate 0.391
- REVEL 0.27
- MetaLR 0.30
- MetaSVM -0.58
- CADD 22.80
- PolyPhen-2 0.84
- SIFT 0.54
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available