G75D (p.Gly75Asp) variant of PLAU (P00749)
G75D (p.Gly75Asp) in PLAU (P00749) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.85 / 1. The record also includes population frequency data and structural context.
G75D (p.Gly75Asp) variant details
- p.Gly75Asp
- NCI-TCGA Cosmic COSV6564
- cosmic curated COSV65641
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.848
- REVEL 0.87
- MetaLR 0.83
- MetaSVM 0.90
- CADD 28.90
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available