R32T (p.Arg32Thr) variant of PLAT (P00750)
R32T (p.Arg32Thr) in PLAT (P00750) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.72 / 1. The record also includes population frequency data and structural context.
R32T (p.Arg32Thr) variant details
- p.Arg32Thr
- rs1390184489
- NCI-TCGA Cosmic COSV5427
- cosmic curated COSV54277
- gnomAD rs1390184489
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.719
- REVEL 0.70
- CADD 32.00
- PolyPhen-2 1.00
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available