G35R (p.Gly35Arg) variant of PINK1 (Q9BXM7)
G35R (p.Gly35Arg) in PINK1 (Q9BXM7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, published literature, and structural context.
G35R (p.Gly35Arg) variant details
- p.Gly35Arg
- gnomAD 1-20633651-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.461
- REVEL 0.40
- CADD 23.20
- PolyPhen-2 0.92
- SIFT 0.17
- Most common in the Latino/Admixed American population (allele frequency 0.00011)
- Structural context available
- Literature evidence available