S51W (p.Ser51Trp) variant of PIM1 (P11309)
S51W (p.Ser51Trp) in PIM1 (P11309) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
S51W (p.Ser51Trp) variant details
- p.Ser51Trp
- rs551680157
- NCI-TCGA Cosmic COSV6516
- 1000Genomes rs551680157
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.524
- REVEL 0.41
- CADD 28.40
- PolyPhen-2 0.98
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available