P33S (p.Pro33Ser) variant of PIM1 (P11309)
P33S (p.Pro33Ser) in PIM1 (P11309) is a missense change. Clinical records from ClinVar and UniProt describe it as tier iii - unknown in the context of Primary central nervous system lymphoma. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
P33S (p.Pro33Ser) variant details
- p.Pro33Ser
- rs775870535
- NCI-TCGA Cosmic COSV6516
- 1000Genomes rs775870535
- Tier III - Unknown
- Primary central nervous system lymphoma
- Missense
- Variant Prioritization Score for Impact Estimate 0.347
- REVEL 0.09
- CADD 21.60
- PolyPhen-2 0.01
- SIFT 0.51
- ClinVar: Tier III - Unknown (Primary central nervous system lymphoma)
- UniProt: Tier iii - unknown
- Most common in the 1KG:YRI population (allele frequency 0.0043)
- Structural context available