G28D (p.Gly28Asp) variant of PIM1 (P11309)
G28D (p.Gly28Asp) in PIM1 (P11309) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
G28D (p.Gly28Asp) variant details
- p.Gly28Asp
- rs377274719
- NCI-TCGA Cosmic COSV6516
- 1000Genomes rs377274719
- ESP rs377274719
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.354
- REVEL 0.08
- CADD 24.40
- PolyPhen-2 0.23
- SIFT 0.09
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available