L26F (p.Leu26Phe) variant of PIK3R1 (P27986)
L26F (p.Leu26Phe) in PIK3R1 (P27986) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
L26F (p.Leu26Phe) variant details
- p.Leu26Phe
- cosmic curated COSV99161
- TOPMed rs1001383254
- gnomAD rs1001383254
- Missense
- Variant Prioritization Score for Impact Estimate 0.269
- REVEL 0.07
- CADD 24.00
- PolyPhen-2 0.48
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available