Y6C (p.Tyr6Cys) variant of PIK3CG (P48736)
Y6C (p.Tyr6Cys) in PIK3CG (P48736) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
Y6C (p.Tyr6Cys) variant details
- p.Tyr6Cys
- rs757808746
- NCI-TCGA Cosmic COSV6324
- cosmic curated COSV63247
- ExAC rs757808746
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.192
- REVEL 0.20
- MetaLR 0.17
- MetaSVM -0.90
- CADD 10.80
- PolyPhen-2 0.00
- SIFT 0.19
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available