R26C (p.Arg26Cys) variant of PIK3CG (P48736)
R26C (p.Arg26Cys) in PIK3CG (P48736) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
R26C (p.Arg26Cys) variant details
- p.Arg26Cys
- NCI-TCGA Cosmic COSV6324
- cosmic curated COSV63247
- TOPMed rs1790340029
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.359
- REVEL 0.12
- MetaLR 0.18
- MetaSVM -0.91
- CADD 22.30
- PolyPhen-2 0.18
- SIFT 0.17
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available