R20C (p.Arg20Cys) variant of PIK3CG (P48736)
R20C (p.Arg20Cys) in PIK3CG (P48736) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
R20C (p.Arg20Cys) variant details
- p.Arg20Cys
- NCI-TCGA Cosmic COSV6324
- cosmic curated COSV63245
- Ensembl rs2116417261
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.505
- REVEL 0.34
- MetaLR 0.47
- MetaSVM -0.07
- CADD 26.00
- PolyPhen-2 0.99
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available