R4P (p.Arg4Pro) variant of PIK3CA (P42336)
R4P (p.Arg4Pro) in PIK3CA (P42336) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes structural context.
R4P (p.Arg4Pro) variant details
- p.Arg4Pro
- rs749956691
- ClinGen CA355270140
- ClinVar RCV001761056
- ExAC rs749956691
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.465
- AlphaMissense 0.67
- MetaLR 0.38
- MetaSVM -0.43
- PolyPhen-2 1.00
- SIFT 0.10
- MutPred 0.37
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available