R4* (p.Arg4Ter) variant of PIK3CA (P42336)
R4* (p.Arg4Ter) in PIK3CA (P42336) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
R4* (p.Arg4Ter) variant details
- p.Arg4Ter
- rs1051397
- NCI-TCGA Cosmic COSV5596
- cosmic curated COSV55961
- TOPMed rs1051397
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.556
- CADD 35.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Non-Finnish European population (allele frequency 2.3e-05)
- Structural context available